None know other than reversible effect of overdose. Overdosage will result in a return of symptoms after the symptoms have initially disappeared. Where a return of symptoms occur while on the medication, ceasing to use will alleviate the effect. Patients who are hypersensitive to homeopathic preparations will show response to a single dose, which may not need to be repeated for some time. For this reason therapy should always start with a single dose the previous day and should a major response be seen, therapy should not be recommenced until symptoms relapse and then only a single dose given for maximum effect. Although there is no evidence that there are any safety issues, extra care should always be taken when dealing with pregnant animals. Should a suspected adverse reaction be seen or advice needed, please contact HomeoPet, LLC. Contact your veterinarian if problems persist.